Synthesis of a KIF18A inhibitor

The present invention relates to improved preparation of a KIF18A inhibitor having the following chemical structure: (Compound 1), or a salt thereof (Compound 1a); wherein HA is as defined herein; and key intermediates thereof, i.e., Compound 2a, Compound 3a, Compound 5 or a salt thereof, and Compou...

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Bibliographic Details
Main Authors CAILLE, SEBASTIEN, GREENE, DANIEL GERARD, WEI, CAROLYN, CORBETT, MICHAEL THOMAS
Format Patent
LanguageChinese
English
Published 01.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to improved preparation of a KIF18A inhibitor having the following chemical structure: (Compound 1), or a salt thereof (Compound 1a); wherein HA is as defined herein; and key intermediates thereof, i.e., Compound 2a, Compound 3a, Compound 5 or a salt thereof, and Compound 6a or a hydrate thereof, of the formulae: (Compound 2a); (Compound 3a); (Compound 5) or a salt thereof; and (Compound 6a) or a hydrate thereof, preferably (Compound 6a-I). The present invention further relates to solid form of Compound 6a, preferably the crystalline hydrate form of Compound 6a-I.
Bibliography:Application Number: TW202312103047