Drug conjugates of glucocorticoids

The present disclosure relates to drug conjugates of glucocorticoids. Specifically, the present disclosure relates to the antibody-drug conjugate shown in formula (I), wherein Ab is the antibody or its antigen-binding segment, L is the linker that covalently connects Ab to D, and k is 1 to 20, D is...

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Main Authors REN, WEN-MING, ZHOU, CAI-HONG, LIAO, CHENG, CHEN, HAO, HUANG, JIAN, ZHU, LING-JIAN, TANG, MAN-PING, LIN, YUAN
Format Patent
LanguageChinese
English
Published 16.10.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The present disclosure relates to drug conjugates of glucocorticoids. Specifically, the present disclosure relates to the antibody-drug conjugate shown in formula (I), wherein Ab is the antibody or its antigen-binding segment, L is the linker that covalently connects Ab to D, and k is 1 to 20, D is the glucocorticoid or its residue, and the glucocorticoid is selected from Budesonide or Cyclosonide. Ab-(L-D)k (I).
Bibliography:Application Number: TW202312102805