Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer

The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compou...

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Main Authors BROEKER, JOACHIM, FUCHS, JULIAN, WILDING, BIRGIT, RAMHARTER, JUERGEN, HODGES, TIM, HERDEIS, LORENZ, CUI, JIAN-WEN, MANTOULIDIS, ANDREAS, SMETHURST, CHRISTIAN ALAN PAUL, FESIK, STEPHEN W, TREU, MATTHIAS, ABBOTT, JASON, LITTLE, ANDREW, PHAN, JASON, WATERSON, ALEX, SUN, QI, SARKAR, DHRUBA, WUNBERG, TOBIAS
Format Patent
LanguageChinese
English
Published 01.10.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
AbstractList The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
Author HERDEIS, LORENZ
HODGES, TIM
SUN, QI
BROEKER, JOACHIM
LITTLE, ANDREW
TREU, MATTHIAS
WUNBERG, TOBIAS
WILDING, BIRGIT
WATERSON, ALEX
MANTOULIDIS, ANDREAS
SARKAR, DHRUBA
PHAN, JASON
RAMHARTER, JUERGEN
FESIK, STEPHEN W
FUCHS, JULIAN
ABBOTT, JASON
CUI, JIAN-WEN
SMETHURST, CHRISTIAN ALAN PAUL
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VANDERBILT UNIVERSITY
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Snippet The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims...
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HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
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