Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer

The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compou...

Full description

Saved in:
Bibliographic Details
Main Authors BROEKER, JOACHIM, FUCHS, JULIAN, WILDING, BIRGIT, RAMHARTER, JUERGEN, HODGES, TIM, HERDEIS, LORENZ, CUI, JIAN-WEN, MANTOULIDIS, ANDREAS, SMETHURST, CHRISTIAN ALAN PAUL, FESIK, STEPHEN W, TREU, MATTHIAS, ABBOTT, JASON, LITTLE, ANDREW, PHAN, JASON, WATERSON, ALEX, SUN, QI, SARKAR, DHRUBA, WUNBERG, TOBIAS
Format Patent
LanguageChinese
English
Published 01.10.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
Bibliography:Application Number: TW202211145890