Stopper placement in a syringe

• Main Authors: ABBAS, SHERMEEN A, FALLAHIANBIJAN, FATEMEH, MISMAR, WAEL, GONZALES, OSCAR, PADMAKUMAR, VIKASHNI, BROWN, JEFFREY A, JU, ALBERT
• Format: Patent
• Language: Chinese; English
• Published: 16.09.2023
• Subjects: CONVEYING; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; HANDLING THIN OR FILAMENTARY MATERIAL; HUMAN NECESSITIES; HYGIENE; MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGINGARTICLES OR MATERIALS; MEDICAL OR VETERINARY SCIENCE; PACKING; PERFORMING OPERATIONS; STORING; TRANSPORTING; UNPACKING

A method of placing a plunger into a syringe barrel filled with a drug product. The method includes aligning a stopper with a longitudinal axis of a syringe barrel. The syringe barrel includes a proximal end, a distal end, and a reservoir. The drug product is disposed in the reservoir at the distal end. The method includes applying a vacuum pressure to the reservoir of the syringe barrel. The method includes pushing the stopper with a plunger rod into the reservoir of the syringe barrel to a first depth. The method includes removing the plunger rod from the reservoir of the syringe barrel after pushing the stopper to the first depth. The stopper migrates to a second depth that is different than the first depth in response to a pressure differential in the reservoir of the syringe barrel.