Anti-IL-17/VEGF bifunctional fusion protein and use thereof

• Main Authors: DENG, LAN, ZHU, ZHEN-PING, WANG, LI-HUA, MENG, YUN, HUANG, HAO-MIN, LIU, LI-FEN
• Format: Patent
• Language: Chinese; English
• Published: 01.09.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to the technical field of fusion proteins, in particular to an anti-IL-17/VEGF bifunctional fusion protein and use thereof. The anti-IL-17/VEGF bifunctional fusion protein comprises an anti-IL-17 antibody and a protein specifically binds to VEGF, that the protein specifically binds to VEGF is VEGFR. The protein that specifically binds to VEGF is linked to the anti-IL-17 antibody directly or through a linker. The anti-IL-17/VEGF bifunctional fusion protein can simultaneously block the IL-17 and VEGF signaling pathways, and can be used for the preparation of therapeutic medication to the diseases of overexpressing IL-17 and/ or VEGF.