Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof

The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

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Bibliographic Details
Main Authors KANE, TIM, WU, JEFFREY, PALMER, WYLIE SOLANG, OZBOYA, KEREM, LEE, JOHN
Format Patent
LanguageChinese
English
Published 16.04.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.
Bibliography:Application Number: TW202211131116