Lactams as CBL-B inhibitors

Various amide and lactam compounds that binds Cbl-B, and is selective for C-Cbl, and methods of making and using the same. Representative lactam compounds of the invention include: and.

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Bibliographic Details
Main Authors LAROUCHE-GAUTHIER, ROBIN, UNG, MAN UN, LAMBRECHT, MICHAEL JOHN, HUESTIS, MALCOLM, YADAV, ARUN, BROCCATELLI, FABIO, LIANG, JUN, WANG, XIAOJING, ZBIEG, JASON ROBERT, JAKALIAN, ARAZ
Format Patent
LanguageChinese
English
Published 01.02.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Various amide and lactam compounds that binds Cbl-B, and is selective for C-Cbl, and methods of making and using the same. Representative lactam compounds of the invention include: and.
Bibliography:Application Number: TW202211104421