Drug conjugates of glucocorticoid receptor agonists and their applications in medicine

• Main Authors: REN, WEN-MING, DENG, MENG-DIE, ZHANG, JING-YANG, LIAO, CHENG, SU, LU, ZHANG, LIAN-SHAN, LIN, KAN, HUANG, JIAN, ZHU, LING-JIAN, TANG, MAN-PING, HONG, MIN
• Format: Patent
• Language: Chinese; English
• Published: 01.12.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

The present disclosure relates to drug conjugates of glucocorticoid receptor agonists and their use in medicine. Specifically, the present disclosure relates to an antibody-drug conjugate represented by formula (I): Ab-(L-D)k(I), wherein Ab is an antibody or an antigen-binding fragment thereof, and...