Controlled release pharmaceutical compositions in a monolithic matrix tablet form comprising rebamipide and processes for preparing the same

The present invention provides a controlled release pharmaceutical composition in a monolithic matrix tablet form for oral administration in twice a day, comprising rebamipide as an active ingredient; and a combination of a water-soluble saccharide and hypromellose as a release-controlling agent and...

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Bibliographic Details
Main Authors KIM, JU-HEE, KIM, HYUNG-MIN, HONG, EUI-SEOK, CHO, SUNG-JO, LEE, TAW-WON
Format Patent
LanguageChinese
English
Published 16.07.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a controlled release pharmaceutical composition in a monolithic matrix tablet form for oral administration in twice a day, comprising rebamipide as an active ingredient; and a combination of a water-soluble saccharide and hypromellose as a release-controlling agent and a process for preparing the same. The controlled release pharmaceutical composition of the present invention may be easily prepared through a conventionally used process for manufacturing tablets, and thus can be easily applied at production sites. In addition, the controlled release pharmaceutical composition of the present invention may be formulated to have a size suitable for allowing even elderly patients' taking, which makes it possible to increase patients' drug compliance.
Bibliography:Application Number: TW202110132046