Trispecific and/or trivalent binding proteins for prevention or treatment of HIV infection

Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the...

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Main Authors KWON, YOUNG DO, BENINGA, JOCHEN, WEI, RONNIE, XU, LING, LANGE, CHRISTIAN, DORIA-ROSE, NICOLE A, CONNORS, MARK, KRUIP, JOCHEN, BEIL, CHRISTIAN, NABEL, GARY J, QIU, HUAWEI, ASOKAN, MANGAIARKARASI, RAO, ERCOLE, YANG, ZHI-YONG, ZHOU, TONGQING, KOUP, RICHARD A, PEGU, AMARENDRA, MASCOLA, JOHN R, KWONG, PETER D, LEUSCHNER, WULF DIRK, HUANG, JINGHE
Format Patent
LanguageChinese
English
Published 16.05.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.
Bibliography:Application Number: TW202110126977