Intermediates and methods for preparing a GLP-1 receptor agonist

The present invention relates to a methods and key intermediates useful for preparing the GLP-1 receptor agonist (S)-2-(3S,8S)-3-(4-(3,4-dichlorobenzyloxy)phenyl-7-((S)-1-phenylpropyl)- 2,3,6,7,8,9-hexahydro-[1,4]-dioxino[2,3-g]isoquinolin-8-ylformylamino)-3-(4-(2,3-dimethylpyridin-4-yl)phenyl)propa...

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Bibliographic Details
Main Authors POLISETTI, DHARMA RAO, YOKUM, THOMAS SCOTT, SUN, YUANQIANG
Format Patent
LanguageChinese
English
Published 16.02.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a methods and key intermediates useful for preparing the GLP-1 receptor agonist (S)-2-(3S,8S)-3-(4-(3,4-dichlorobenzyloxy)phenyl-7-((S)-1-phenylpropyl)- 2,3,6,7,8,9-hexahydro-[1,4]-dioxino[2,3-g]isoquinolin-8-ylformylamino)-3-(4-(2,3-dimethylpyridin-4-yl)phenyl)propanoic acid dihydrochloride ("OAD2 dihydrochloride"). The methods may be run on industrial scale and in higher yield than previously disclosed methods.
Bibliography:Application Number: TW202110119058