Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same

The present disclosure provides prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenoside nucleosides, and compositions, methods, and kits thereof. Such compounds can be useful for treating viral infections including, but not limited to, human immunodeficiency virus.

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Bibliographic Details
Main Authors JANSA, PETR, SQUIRES, NEIL H, CHUN, BYOUNG-KWON, NADUTHAMBI, DEVAN, BYUN, DANIEL H, CLARKE, MICHAEL O, MACKMAN, RICHARD L
Format Patent
LanguageChinese
English
Published 01.01.2022
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The present disclosure provides prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenoside nucleosides, and compositions, methods, and kits thereof. Such compounds can be useful for treating viral infections including, but not limited to, human immunodeficiency virus.
Bibliography:Application Number: TW202110110091