Methylation of MCL-1 compounds

Disclosed herein is an improved process for the synthesis of compound A: (A), or a salt or solvate thereof via methylation of compound B: (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound A.

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Bibliographic Details
Main Authors HUCKLE, JAMES E, TOM, JANINE K, BROWN, SEAN, ACHMATOWICZ, MICHAL, WU, TIAN, HWANG, TSANG-LIN, CUI, SHENG, LANGILLE, NEIL FRED, STEC, MARKIAN
Format Patent
LanguageChinese
English
Published 01.11.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein is an improved process for the synthesis of compound A: (A), or a salt or solvate thereof via methylation of compound B: (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound A.
Bibliography:Application Number: TW202110111735