Therapeutic combinations comprising ubiquitin-specific-processing protease 1 (USP1) inhibitors and poly (ADP-ribose) polymerase (PARP) inhibitors

• Main Authors: LIU, HANLAN, SINKEVICIUS, KERSTIN WOLF, CADZOW, ANNE LOUISE, WYLIE, ANDREW ALISTAIR, SULLIVAN, PAMELA JEAN, SHENKER, SOLOMON MARTIN, STEGMEIER, FRANK
• Format: Patent
• Language: Chinese; English
• Published: 01.11.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides therapeutic combinations comprising (i) a ubiquitin-specific-processing protease 1 (USP1) inhibitor and (ii) a poly ADP-ribose polymerase (PARP) inhibitor, or a pharmaceutically acceptable salt, hydrate, solvate, amorphous solid, or polymorph thereof, wherein the USP1 inhibitor comprises, or pharmaceutically acceptable salts, hydrates, solvates, amorphous solids, or polymorphs thereof. The present disclosure is also directed to the use of the combinations to inhibit a USP1 and/or PARP protein and/or to treat a disorder responsive to the inhibition of USP1 and/or PARP proteins and USP1 and/or PARP activity. The combinations of the present disclosure are especially useful for treating cancer.