Solid forms of 2-((4-((S)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d] [1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d] imidazole-6-carboxylic acid, 1,3-dihydroxy-2-(hydroxymethyl)propan-2-amine salt

• Main Authors: CURTO, JOHN M, ASPNES, GARY ERIK, LIMBERAKIS, CHRIS, EDMONDS, DAVID JAMES, FLANAGAN, MARK EDWARD, MATHIOWETZ, ALAN MARTIN, RUGGERI, ROGER B, PIOTROWSKI, DAVID WALTER, GRIFFITH, DAVID ANDREW, LONDREGAN, ALLYN TIMOTHY, KIM, HUARD, LIAN, YAJING, CLARK, WESLEY, FUTATSUGI, KENTARO, BAGLEY, SCOTT WILLIAM
• Format: Patent
• Language: Chinese; English
• Published: 01.10.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides solid forms of 2-((4-((S)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid, 1,3-dihydroxy-2-(hydroxymethyl)propan-2-amine salt for example, a hydrate (e.g. a monohydrate) crystalline form (e.g. Form 2 or Form 3) or an amorphous form; as well as pharmaceutical compositions, and the uses thereof in treating diseases, conditions or disorders modulated by GLP-1R in a mammal, such as a human.