Methods of treatment with myosin modulator

Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in c...

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Main Authors MA, YANFEI, MCDOWELL, ROBERT, LI, WAN-YING, FERNANDES, SARAH, KANE, BRIAN EDMUND, NISSEN, STEVE E, EDELBERG, JAY M, HENZE, MARCUS PATRICK, SEHNERT, AMY, LAMBING, JOSEPH, SEHL, LOUIS CHARLES, SEMIGRAN, MARC J, ZHANG, DAVID, LAMPL, KATHY L, FANG, LIANG, DEL RIO, CARLOS L, CARLSON, TIMOTHY, DESAI, MILIND Y, MEALIFFE, MATTHEW EDWARDS, AUBELE, DANIELLE L
Format Patent
LanguageChinese
English
Published 16.09.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.
Bibliography:Application Number: TW20209139230