Enhanced performance of amorphous solid and solubilized formulations for achieving therapeutic plasma concentrations

This invention relates to solid amorphous dispersions comprising Compound (I) having the formula and one or more polymers or to solution formulations comprising Compound (I) and one or more co-solvents and surfactants. The formulations exhibit enhanced stability and bioavailability.

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Bibliographic Details
Main Authors ZIEMBA, THERESA M, PATTASSERI, SHABEERALI, REDDY, JAY POORNA, NARASIMHAMURTHY, ROOPA, PAL, SHARMISTHA, STEFANSKI, KEVIN J, WAKNIS, VRUSHALI M, SRIDHAR, SRIKANTH KORAVADY, PANDURANGA, NARAYAN SWAMY, GARMISE, ROBERT J, CHOWAN, GAJENDRA SINGH, LEVONS, JAQUAN KALANI, SAXENA, AJAY
Format Patent
LanguageChinese
English
Published 01.02.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to solid amorphous dispersions comprising Compound (I) having the formula and one or more polymers or to solution formulations comprising Compound (I) and one or more co-solvents and surfactants. The formulations exhibit enhanced stability and bioavailability.
Bibliography:Application Number: TW20209112257