2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors

Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA'): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, i...

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Main Authors FLEURY, MELISSA, SUTTON, JAMES, NEWBY, ZACHARY E. R, KNOX, JOHN E, CLEARY, LEAH, PEI, ZHONGHUA, ALAM, MUZAFFAR, STEEL, RICHARD
Format Patent
LanguageChinese
English
Published 01.11.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA'): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
Bibliography:Application Number: TW20198145188