Novel bispecific agonistic 4-1BB antigen binding molecules
The invention relates to new bispecific antigen binding molecules, comprising (a) a first Fab fragment capable of specific binding to 4-1BB, (b) a second Fab fragment capable of specific binding to a target cell antigen, (c) a third Fab fragment capable of specific binding to 4-1BB, and (d) a Fc dom...
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Main Authors | , , , , |
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Format | Patent |
Language | Chinese English |
Published |
01.10.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to new bispecific antigen binding molecules, comprising (a) a first Fab fragment capable of specific binding to 4-1BB, (b) a second Fab fragment capable of specific binding to a target cell antigen, (c) a third Fab fragment capable of specific binding to 4-1BB, and (d) a Fc domain composed of a first and a second subunit capable of stable association, wherein the Fab fragments (a) and (b) are fused to each other, and to methods of producing these molecules and to methods of using the same. |
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Bibliography: | Application Number: TW20198123224 |