Antibodies binding to VISTA at acidic pH

The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significa...

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Main Authors CRITTON, DAVID A, DENG, XIAODI, RAKESTRAW, GINGER, QUIGLEY, MICHAEL, LEMAR, HADIA, SU, LIN HUI, DEYANOVA, EKATERINA G, RANKIN, ANDREW, RAJPAL, ARVIND, PINCKNEY, JASON R, KORMAN, ALAN J, RORGES, LUIS, HUANG, RICHARD Y, JOHNSTON, ROBERT J, CHEN, GUODONG, SHEPPARD, PAUL O, BAHJAT, KEITH SADOON
Format Patent
LanguageChinese
English
Published 01.08.2020
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
Bibliography:Application Number: TW20190124306