Method for screening for components that improve condition of aged or hypoxic skin, and method for estimating oxygen level of subdermal tissue or fibrosis level of subdermal adipocytes as index of subdermal tissue viscoelasticity

• Main Authors: MOCHIZUKI, MAYU, KUROZUMI, MOTOKI, MIZUKOSHI, KOJI, HAMANAKA, YOSHIHIRO, KURIBAYASHI, MARI
• Format: Patent
• Language: Chinese; English
• Published: 01.04.2020
• Subjects: DIAGNOSIS; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; SURGERY; TESTING

The first problem to be solved by the present invention is to provide a novel technique for screening for components that are effective in suppressing the deterioration of collagen structures in a subject. To solve the first problem, the present invention provides a method for screening for components that suppress the deterioration of collagen structures due to hypoxic conditions and/or aging, the method being characterized by using, as an index, the effectiveness in reducing increases in collagen fiber bundle formation when a test component is added to a collagen-containing composition in which cells are dispersed, and the composition is incubated in hypoxic conditions.