Amino acid compounds with unbranched linkers and methods of use

The invention relates to compounds of formula (A): or a salt thereof, wherein R1, R2, R5a, R5b, R6a, R6b, R7a, R7b, R8a, R8b, R9a, R9b, R10a, R10b, R11a, R11b, R21, n, and G are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are [alpha]V[beta]6 integrin inhibit...

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Main Authors BAILEY, CHRISTOPHER, LEFTHERIS, KATERINA, REILLY, MAUREEN, FINKELSTEIN, DARREN, CHA, JACOB, COOPER, NICOLE
Format Patent
LanguageChinese
English
Published 16.03.2020
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Summary:The invention relates to compounds of formula (A): or a salt thereof, wherein R1, R2, R5a, R5b, R6a, R6b, R7a, R7b, R8a, R8b, R9a, R9b, R10a, R10b, R11a, R11b, R21, n, and G are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are [alpha]V[beta]6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
Bibliography:Application Number: TW20198122460