Substituted macrocyclic indole derivatives

The present invention relates to substituted macrocyclic indole derivatives of general formula(I):, in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combina...

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Main Authors KLAR, ULRICH, FERNANDEZ-MONTALVAN, AMAURY ERNESTO, MCCARREN, PATRICK RYAN, MENGEL, ANNE, LEMKE, CHRIS, MONNING, URSULA, LAZARSKI, KIEL, FERRARA, STEVEN JAMES, CHRIST, CLARA, NOWAK-REPPEL, KATRIN, NASVESCHUK, CHRISTOPHER, WEI, GUO, KAULFUSS, STEFAN, SACK, ULRIKE, FURST, LAURA, MCKINNEY, DAVID, SERRANO-WU, MICHAEL H, HARVEY, REBECCA ANN, JOHANNES, SARAH ANNA LIESA, FITZGERALD, MARK, KUHNKE, JOACHIM, WERBECK, NICOLAS, WITTROCK, SVEN, THEDE, KAI, BUCHGRABER, PHILIPP
Format Patent
LanguageChinese
English
Published 16.09.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to substituted macrocyclic indole derivatives of general formula(I):, in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
Bibliography:Application Number: TW20187140647