Quinazoline compound

Provided is a compound which is useful as an active ingredient of a pharmaceutical composition for treating lung cancer. The present inventors have studied a compound useful as an active ingredient of a pharmaceutical composition for treating lung cancer, and as a result, it was found that a quinazo...

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Main Authors WATANABE, KAZUSHI, NIGAWARA, TAKAHIRO, KUNIKAWA, SHIGEKI, ARAKAWA, KEISUKE, SHIMADA, ITSURO, IMAIZUMI, TOMOYOSHI, SATAKE, YOSHIKI, YAMAKI, SUSUMU, ARAKI, TAKANOBU, SHIMAZAKI, MASASHI, KOIKE, TAKANORI, KURAMOTO, KAZUYUKI, AKAIWA, MICHINORI, ABE, TOMOAKI
Format Patent
LanguageChinese
English
Published 01.11.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided is a compound which is useful as an active ingredient of a pharmaceutical composition for treating lung cancer. The present inventors have studied a compound useful as an active ingredient of a pharmaceutical composition for treating lung cancer, and as a result, it was found that a quinazoline compound has an excellent G12C mutation KRAS inhibitory activity, and which can be used as a therapeutic agent for lung cancer, and thereby the present invention has been completed. The quinazoline compound of the present invention and a salt thereof may be used as the therapeutic agent for lung cancer.
Bibliography:Application Number: TW20187103604