Binder-drug conjugates (ADCs) having enzymatically cleavable groups

• Main Authors: STELTE-LUDWIG, BEATRIX, KIRCHHOFF, DENNIS, MAERSCH, STEPHAN, REBSTOCK, ANNE-SOPHIE, SOMMER, ANETTE, HAMMER, STEFANIE, BERNDT, SANDRA, MAHLERT, CHRISTOPH, DIETZ, LISA, LERCHEN, HANS-GEORG, GREVEN, SIMONE
• Format: Patent
• Language: Chinese; English
• Published: 01.08.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use...