Binder-drug conjugates (ADCs) having enzymatically cleavable groups

The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use...

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Main Authors STELTE-LUDWIG, BEATRIX, KIRCHHOFF, DENNIS, MAERSCH, STEPHAN, REBSTOCK, ANNE-SOPHIE, SOMMER, ANETTE, HAMMER, STEFANIE, BERNDT, SANDRA, MAHLERT, CHRISTOPH, DIETZ, LISA, LERCHEN, HANS-GEORG, GREVEN, SIMONE
Format Patent
LanguageChinese
English
Published 01.08.2018
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.
Bibliography:Application Number: TW20170144529