TAT[kappa]-CDKL5 fusion proteins, compositions, formulations, and use thereof

Disclosed herein are compositions and formulations containing a TAT[kappa]-CDKL5 fusion protein. Also disclosed are methods of producing a TAT[kappa]-CDKL5 fusion protein from vectors containing a TAT[kappa]-CDKL5 cDNA and methods of transducing cells with the vectors containing a TAT[kappa]-CDKL5 c...

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Bibliographic Details
Main Authors LACCONE, FRANCO, CIANI, ELISABETTA
Format Patent
LanguageChinese
English
Published 01.02.2018
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are compositions and formulations containing a TAT[kappa]-CDKL5 fusion protein. Also disclosed are methods of producing a TAT[kappa]-CDKL5 fusion protein from vectors containing a TAT[kappa]-CDKL5 cDNA and methods of transducing cells with the vectors containing a TAT[kappa]-CDKL5 cDNA and the TAT[kappa]-CDKL5 fusion protein. Also disclosed are uses of TAT[kappa]-CDKL5 fusion proteins for treating CDKL5 deficiencies by systemic or intravenous administration of the fusion proteins.
Bibliography:Application Number: TW20176121604