Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof

The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.

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Bibliographic Details
Main Authors BRADNER, JAMES E, HUANG, GUOXIANG, VAN DUZER, JOHN H, MAZITSCHEK, RALPH, XIE, DEJIAN, OGIER, WALTER, YU, NAN
Format Patent
LanguageChinese
English
Published 16.10.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
Bibliography:Application Number: TW20176121994