Anti-TL1A/anti-TNF-[alpha] bispecific antigen binding proteins and uses thereof
The present invention concerns antigen binding proteins that bind TL1A, including bispecific antigen binding proteins (e.g., antibodies) to TL1A and TNF-[alpha]. Such bispecific antibodies can be in a conventional tetrameric immunoglobulin format, in which one heavy chain-light chain pair of the ant...
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Main Authors | , , , , |
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Format | Patent |
Language | Chinese English |
Published |
16.09.2017
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention concerns antigen binding proteins that bind TL1A, including bispecific antigen binding proteins (e.g., antibodies) to TL1A and TNF-[alpha]. Such bispecific antibodies can be in a conventional tetrameric immunoglobulin format, in which one heavy chain-light chain pair of the antibody is directed to TL1A and the other to TNF-[alpha] The bispecific antigen binding proteins may also be comprised in a IgG-scFv fusion, in which a conventional tetrameric antibody directed to one antigen is fused to a pair of single chain Fv units directed to the other. The invention further relates to uses of the anti-TL1A binding proteins and anti-TL1A/anti-TNF-[alpha] antigen binding proteins, and pharmaceutical formulations thereof. |
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Bibliography: | Application Number: TW20165141920 |