Oligonucleotide compositions and methods thereof

Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In so...

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Main Authors ZHANG, JASON JINGXIN, LU, GENLIANG, MARAPPAN, SUBRAMANIAN, VARGEESE, CHANDRA, VERDINE, GREGORY L, BUTLER, DAVID CHARLES DONNELL, YANG, HAILIN, FRANK-KAMENETSKY, MARIA DAVID, DIVAKARAMENON, SETHUMADHAVAN, FRANCIS, CHRISTOPHER J, IWAMOTO, NAOKI, MEENA
Format Patent
LanguageChinese
English
Published 01.07.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.
Bibliography:Application Number: TW20165132669