Production process of crystal of diazabicycleoctane derivative and stable lyophilized preparation

An objective of this invention is to provide a process for easily producing a crystal of compound (I) in industrial scale and a stable lyophilized composition of compound (I). The present invention provides a lyophilized composition in which the compound (I) is crystal and excellent in stability by...

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Main Authors OGAWA, TAKAYA, YOKOYAMA, TAKUYA, ICHIKI, MASATO, FUSHIHARA, KENICHI, FURUYAMA, SHUSUKE
Format Patent
LanguageChinese
English
Published 16.08.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:An objective of this invention is to provide a process for easily producing a crystal of compound (I) in industrial scale and a stable lyophilized composition of compound (I). The present invention provides a lyophilized composition in which the compound (I) is crystal and excellent in stability by lyophilizing an aqueous solution containing compound (I) and inorganic salts such as sodium chloride. In addition, even the lyophilized process is not conduct, a crystal of compound (I) can also be obtained from the aqueous solution.
Bibliography:Application Number: TW20154140714