Substituted azole compound and antidiabetes agent

• Main Authors: SHINTANI, YUSUKE, MONMA, SOUICHI, SHIGETA, YUKIHIRO, KAMIYAMA, TOSHIHIKO, NIWA, MASATOSHI, SHIMAZAWA, YOSHINOBU, OKADA, KAZUAKI, ISHIYAMA, SEISHI
• Format: Patent
• Language: Chinese; English
• Published: 16.07.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

To provide a novel substituted azole compound having a GPR119-activating activity and useful particularly for the prevention and/or treatment of diabetes and obesity. Provided are: a novel substituted azole compound represented by formula (I) (wherein each substituent is as defined in detail in the description; the ring A represents an aromatic ring which may be substituted by a substituent as defined in the description; the ring B represents a ring selected from rings represented by formula (II); R1 represents a hydrogen atom, an alkyl group or the like; R2 represents an alkyl group or the like; the ring C represents a benzene ring, a 5- to 6-membered aromatic heterocyclic ring or the like; and R3 and R4 independently represent an alkyl group which may be substituted or the like), a tautomer or pharmaceutically acceptable salt of the compound, or a solvate of the compound or the tautomer or pharmaceutically acceptable salt.