Methods and compositions for treating pain

The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treat...

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Bibliographic Details
Main Authors FANG, JIM-MIN, CHERN, YI-JUANG, CHEN, CHIHNG, LIN, CHIAING JOHN, LIN, CHUN-JUNG, CHEN, WEI-NAN, LIN, YUN-LIAN
Format Patent
LanguageChinese
English
Published 01.02.2016
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenosine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.
Bibliography:Application Number: TW20154119314