Methods of treating pain associated with osteoarthritis of a joint with a topical formulation of a spiro-oxindole compound

Methods of treating pain associated with osteoarthritis of a joint in a mammal with a pharmaceutical composition comprising a spiro-oxindole compound of the formula: are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the synovial membrane of the affected joi...

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Main Authors MALAMUT, RICHARD, SPIEGELSTEIN, OFER, PRICE, NICOLA ANNE, LAMSON, MICHAEL J, NAMDARI, ROSTAM, FETELL, MICHAEL, COHEN, CHARLES JAY, GOLDBERG, YIGAL PAUL, PROCTOR, KATIE JANE WEBSTER
Format Patent
LanguageChinese
English
Published 01.11.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods of treating pain associated with osteoarthritis of a joint in a mammal with a pharmaceutical composition comprising a spiro-oxindole compound of the formula: are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the synovial membrane of the affected joint to effectively reduce the severity of the pain and/or to alleviate the pain with minimal or negligible systemic exposure.
Bibliography:Application Number: TW20154103958