Nitrogenous heterocyclic derivatives and their application in drugs

• Main Authors: WANG, XIAO-JUN, CAO, SHENG-TIAN, ZHANG, JIANCUN, LIN, RUN-FENG, WANG, ZHAO-HE, ZHANG, YING-JUN, LI, JING
• Format: Patent
• Language: Chinese; English
• Published: 16.02.2015
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to the field of drugs and discloses novel nitrogenous heterocyclic derivatives, its manufacturing method and drug uses, especially used for treatment and prevention and treatment of tissue fibrosis. The present invention also discloses a drug composition including the invention and acceptable in pharmacy, and uses by using the composition for treatment of diseases of tissue fibrosis of human or animals, especially uses for the treatment of humen or animals in renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, retroperitoneal fibrosis, myocardial fibrosis, skin fibrosis, post-surgical adhesions, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, muscle tumors, neurofibromatosis, pulmonary fibrosis, diabetes, kidney disease, Alzheimer's disease, or vascular fibrosis.