Protected succinates for enhancing mitochondrial ATP-production

Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optiona...

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Main Authors SCOWEN, DAVID ARTHUR, BATCHELLER, DEREK GREGORY, ELMER, MATS ESKIL, FORD, RHONAN LEE, EHINGER, KARL HENRIK JOHANNES, HANSSON, MAGNUS JOAKIM, FLIRI, HANS GEORG, SJOVALL, KARL FREDRIK LENNART
Format Patent
LanguageChinese
English
Published 16.05.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optionally substituted alkyl group or a group of formula (II) and R2 is independently a group according to formula (II) where formula (II) is as defined herein.
Bibliography:Application Number: TW20132136105