Retinoid-liposomes for enhancing modulation of HSP47 expression

What is described are pharmaceutical compositions comprising a double stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID...

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Bibliographic Details
Main Authors PAYNE, JOSEPH E, LIU, YUN, AKOPIAN, VIOLETTA, KNOPOV, VICTOR, MINOMI, KENJIRO, AHMADIAN, MOHAMMAD, PERELMAN, LOREN A, TANAKA, YASUNOBU, FEINSTEIN, ELENA, AVKIN-NAHUM, SHARON, METT, IGOR, KALINSKI, HAGAR, WITTE, RICHARD P, YING, WENBIN, NIITSU, YOSHIRO
Format Patent
LanguageChinese
English
Published 16.04.2013
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Summary:What is described are pharmaceutical compositions comprising a double stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165), and SERPINH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle. These pharmaceutical compositions are useful to enhance modulation of HSP47 expresson by siRNA.
Bibliography:Application Number: TW20121120615