Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof

The present invention discloses and claims a series of substituted N-heteroaryl bipyrrolidine carboxamides of formula (I). Wherein R1, R2, R3, R4, Q1, Q2, Q3, Q4, X, m and p areas described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore,...

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Bibliographic Details
Main Authors GAO, ZHONGLI, HALL, DANIEL, STEFANY, DAVID
Format Patent
LanguageChinese
English
Published 16.02.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention discloses and claims a series of substituted N-heteroaryl bipyrrolidine carboxamides of formula (I). Wherein R1, R2, R3, R4, Q1, Q2, Q3, Q4, X, m and p areas described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-heteroaryl bipyrrolidine carboxamides of formula (I) and intermediates therefor.
Bibliography:Application Number: TW20110116237