2,3-dihydro-1H-inden-1-yl-2,7-diazaspiro[3.5]nonane derivatives

The present invention provides a compound of Formula (I) (I)or a pharmaceutically salt thereof wherein R1, R2, Ra, L, Z, Z1 and Z2 are as defined herein, that act as Ghrelin antagonists or inverse agonists; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditio...

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Main Authors LONDREGAN, ALLYN TIMOTHY, CAMERON, KIMBERLY O'KEEFE, MCCLURE, KIM FRANCIS, BHATTACHARYA, SAMIT KUMAR, SIMILA, SUVI TUULA MARJUKKA, KUNG, DANIEL WEI-SHUNG, FERNANDO, DILINIE PRASADHINI
Format Patent
LanguageChinese
English
Published 16.12.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a compound of Formula (I) (I)or a pharmaceutically salt thereof wherein R1, R2, Ra, L, Z, Z1 and Z2 are as defined herein, that act as Ghrelin antagonists or inverse agonists; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the antagonism of the Ghrelin receptor.
Bibliography:Application Number: TW20110109022