Aminopyrimidines as Syk inhibitors

• Main Authors: KATTAR, SOLOMON, CHILDERS, KALEEN KONRAD, ANDRESEN, BRIAN M, KNOWLES, SANDRA LEE, GUAY, DANIEL, ROBICHAUD, JOEL S, O'BOYLE, BRENDAN M, FOURNIER, JEAN-FRANCOIS, ALTMAN, MICHAEL D, MACHACEK, MICHELLE R, ARRINGTON, KENNETH L, GAUTHIER, JACQUES YVES, ROMEO, ERIC, OTTE, RYAN D, COTE, BERNARD, BURCH, JASON, REUTERSHAN, MICHAEL H, DUPONT-GAUDET, KRISTINA, GUERIN, DAVID JOSEPH, NORTHRUP, ALAN B, SIU, TONY, ELLIS, JOHN MICHAEL, TROTTER, B. WESLEY, DI FRANCESCO, MARIA EMILIA, LI, CHAO-MIN, LIM, JONG-WON, PETROCCHI, ALESSIA, FISCHER, CHRISTIAN, HAIDLE, ANDREW M, ZHOU, HUA, DONOFRIO, ANTHONY, TAOKA, BRANDON M
• Format: Patent
• Language: Chinese; English
• Published: 01.10.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.