Non-invasive energy upconversion methods and systems for in-situ photobiomodulation

• Main Authors: VO-DINH, TUAN, CHADA, VENKATA GOPAL REDDY, SIMMONS, JOSEPH H, SCAFFIDI, JONATHAN P, BOURKE, FREDERIC A. JR, ZHANG, YAN, LAULY, BENOIT, GREGAS, MOLLY K, FATHI, ZAK, THERIEN, MICHAEL J, AYRES, JENNIFER, ZHANG, ZHEN-YUAN, STANTON, IAN N, WALDER, HAROLD, NORTON, STEPHEN JOHN, STECHER, JOSHUA T
• Format: Patent
• Language: Chinese; English
• Published: 16.02.2011
• Subjects: ELECTROTHERAPY; HUMAN NECESSITIES; HYGIENE; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; RADIATION THERAPY; ULTRASOUND THERAPY

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength 1, to generate a second wavelength 2 of radiation having a higher energy than the first wavelength 1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in th