HCV nucleoside inhibitor

4-Amino-1-((2R, 3S, 4S, 5R)-5-azido-4-hydroxy-5-hydroxymethyl-3- methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for ma...

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Bibliographic Details
Main Authors WINQVIST, ANNA, MARTIN, JOSEPH ARMSTRONG, SMITH, DAVID BERNARD, JOHANSSON, NILS-GUNNAR, KALAYANOV, GENADIY
Format Patent
LanguageChinese
English
Published 16.10.2009
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:4-Amino-1-((2R, 3S, 4S, 5R)-5-azido-4-hydroxy-5-hydroxymethyl-3- methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.
Bibliography:Application Number: TW20080112877