Novel N, N'-2,4-dianilinopyrimidine derivatives, the preparation thereof, their use as medicaments, pharmaceutical compositions and in particular as IKK inhibitors

• Main Authors: BOUABOULA, MONSIF, TONNERRE, BERNARD
• Format: Patent
• Language: Chinese; English
• Published: 16.04.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to the products of formula (I): in which one of R2, R3 and R4 represents hydrogen and the others represent hydrogen, halogen, alkyl or alkoxy; R5 represents hydrogen or halogen; the ring(N) contains 4 to 7 members and is saturated; R1 represents -X1-R7 with X1 representing -(CH2)m-, and R6 represents H, OH, -CH2OH, -CO-N-, -CO2H or -CO2alk, or else R1 represents -X2-R7 with X2 representing in particular -O-, -O-(CH2)n-, -CH(OH)-(CH2)n-, -CO-, -CO-NRc-O-, -CH(N) -, -C=NOH-, -C=N-NH2- or -(CH2)n1-NRc-(CH2)n2-, and R6 represents hydrogen; and R7 represents a heterocycloalkyl, aryl or heteroaryl ring, all optionally substituted; with n, n1, n2=0-3; m=1-3; these products being in any of the isomer forms and the salts, as medicaments, in particular as IKK inhibitors.