Novel N, N'-2,4-dianilinopyrimidine derivatives, the preparation thereof, their use as medicaments, pharmaceutical compositions and in particular as IKK inhibitors

The invention relates to the products of formula (I): in which one of R2, R3 and R4 represents hydrogen and the others represent hydrogen, halogen, alkyl or alkoxy; R5 represents hydrogen or halogen; the ring(N) contains 4 to 7 members and is saturated; R1 represents -X1-R7 with X1 representing -(CH...

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Bibliographic Details
Main Authors BOUABOULA, MONSIF, TONNERRE, BERNARD
Format Patent
LanguageChinese
English
Published 16.04.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to the products of formula (I): in which one of R2, R3 and R4 represents hydrogen and the others represent hydrogen, halogen, alkyl or alkoxy; R5 represents hydrogen or halogen; the ring(N) contains 4 to 7 members and is saturated; R1 represents -X1-R7 with X1 representing -(CH2)m-, and R6 represents H, OH, -CH2OH, -CO-N-, -CO2H or -CO2alk, or else R1 represents -X2-R7 with X2 representing in particular -O-, -O-(CH2)n-, -CH(OH)-(CH2)n-, -CO-, -CO-NRc-O-, -CH(N) -, -C=NOH-, -C=N-NH2- or -(CH2)n1-NRc-(CH2)n2-, and R6 represents hydrogen; and R7 represents a heterocycloalkyl, aryl or heteroaryl ring, all optionally substituted; with n, n1, n2=0-3; m=1-3; these products being in any of the isomer forms and the salts, as medicaments, in particular as IKK inhibitors.
Bibliography:Application Number: TW200897130144