Pyridyl derivatives, their preparation and use

The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor (HIF) mediated signaling. Also disclosed are processes for preparation of these derivatives, and their use in the manu...

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Main Authors BHONDE, MANDAR RAMESH, DAGIA, NILESH MADHUKAR, RATHOS, MAGGIE JOYCE, PARIKH, SAPNA, DEORE, VIJAYKUMAR, KUMAR, SANJAY, KULKARNI-ALMEIDA, ASHA ADRIAN, YEWALKAR, NILAMBARI NILKANTH, JOSHI, KALPANA SANJAY
Format Patent
LanguageChinese
English
Published 01.03.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor (HIF) mediated signaling. Also disclosed are processes for preparation of these derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of cancer and inflammation.
AbstractList The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor (HIF) mediated signaling. Also disclosed are processes for preparation of these derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of cancer and inflammation.
Author DAGIA, NILESH MADHUKAR
PARIKH, SAPNA
KUMAR, SANJAY
JOSHI, KALPANA SANJAY
RATHOS, MAGGIE JOYCE
YEWALKAR, NILAMBARI NILKANTH
KULKARNI-ALMEIDA, ASHA ADRIAN
DEORE, VIJAYKUMAR
BHONDE, MANDAR RAMESH
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– fullname: DEORE, VIJAYKUMAR
– fullname: KUMAR, SANJAY
– fullname: KULKARNI-ALMEIDA, ASHA ADRIAN
– fullname: YEWALKAR, NILAMBARI NILKANTH
– fullname: JOSHI, KALPANA SANJAY
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Snippet The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) and/or...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Pyridyl derivatives, their preparation and use
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