Pyridyl derivatives, their preparation and use

The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor (HIF) mediated signaling. Also disclosed are processes for preparation of these derivatives, and their use in the manu...

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Bibliographic Details
Main Authors BHONDE, MANDAR RAMESH, DAGIA, NILESH MADHUKAR, RATHOS, MAGGIE JOYCE, PARIKH, SAPNA, DEORE, VIJAYKUMAR, KUMAR, SANJAY, KULKARNI-ALMEIDA, ASHA ADRIAN, YEWALKAR, NILAMBARI NILKANTH, JOSHI, KALPANA SANJAY
Format Patent
LanguageChinese
English
Published 01.03.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor (HIF) mediated signaling. Also disclosed are processes for preparation of these derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of cancer and inflammation.
Bibliography:Application Number: TW200897129745