Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds as -secretase inhibitors

The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I: The present invention also provides methods for the use thereof to inhibit -secretase (BACE) and treat -amyloid deposits and neurofibrillary tangles.

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Bibliographic Details
Main Authors MCDEVITT, ROBERT EMMETT, ROBICHAUD, ALBERT JEAN, SOLVIBILE, WILLIAM RONALD, KIM, JI-IN, MALAMAS, MICHAEL SOTIRIOS, PORTE, ALEXANDER MICHAEL, MORRIS, KOI MICHELE, ANTANE, SCHUYLER ADAM
Format Patent
LanguageChinese
English
Published 01.12.2008
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I: The present invention also provides methods for the use thereof to inhibit -secretase (BACE) and treat -amyloid deposits and neurofibrillary tangles.
Bibliography:Application Number: TW200897109933