Synthesis of 1 -fluoro-25-hydroxy-16-23E-diene-26, 27-bishomo-20-epi-cholecalciferol

The invention provides a method of producing 20-methyl vitamin D3 compounds of formula I: The method includes hydroxylation, carbonyl reduction, fluoride substitution, epoxide deoxygenation, and Wittig-type couplings.

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Bibliographic Details
Main Authors USKOKOVIC, MILAN R, MAEHR, HUBERT
Format Patent
LanguageChinese
English
Published 01.10.2008
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention provides a method of producing 20-methyl vitamin D3 compounds of formula I: The method includes hydroxylation, carbonyl reduction, fluoride substitution, epoxide deoxygenation, and Wittig-type couplings.
Bibliography:Application Number: TW20080102791