STAT3/5 activation inhibitor

• Main Authors: OKUNO, MITSUHIRO, HAYASHI, KAZUHIKO, OHI, NAOTO, YANAGIHARA, YASUO, AKAMATSU, SEIJI, YOSHIDA, KENJI, OHBUCHI, YUTAKA, OHNISHI, KENJI, WATANABE, TAKASHI, SEKIGUCHI, KAZUO, SUGIYAMA, KAZUHISA, MOTOYAMA, MASAAKI, KODAMA, TAKESHI, SUZUKI, TAKASHI, KIYONO, KUNIHIKO, SUMIDA, TAKUMI, TANAKA, HIDEO
• Format: Patent
• Language: Chinese; English
• Published: 01.06.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group -CH-, R1 represents a group -Z-R6, in which Z represents a group -CO-, a group -CH(OH)- or the like, R6 represents a 5-to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)- or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.